Protein Details: Gamma-aminobutyric acid receptor subunit gamma-4
Protein ID
ICDB_Pro_0490
Protein Name
Gamma-aminobutyric acid receptor subunit gamma-4
Gene Name
GABRG4
Organism
Gallus gallus (Chicken)
Length
457 amino acids
AlphaFoldDB
AF-P34904-F1-model_v4.pdb
Function
GABA; the major inhibitory neurotransmitter in the vertebrate brain; mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Sequence
MPAMVLLLCLALGPALRSARCESTEEYDYDYLSINKTWVLTPKAQETDATQILNSLLKNYDNKLRPDIGIKPTFIDVDIYVNSIGPVSVIQMEYTIDIFFAQTWYDRRLRFNSTLKALTLNTNMVSRIWIPDTFFRNSKRADSHWITTPNQLLRIWNDGKVLYTLRLTIEAECLLQLQNFPMDTHSCPLVFSSYGYPREEIVYRWRRYSIEVSDQRTWRLYQFDFTGLRNTSEVLRTGAGEYMVMTVSFDLSRRMGYFAIQTYIPCILTVVLSWVSFWIKRDSTPARTSLGITTVLTMTTLSTISRKHLPRVSYITAMDLFVSVCFIFVFAALMEYATLNYLVGNKKPLEHSSRKARLPPAGAQVMPSFTAINININNIMHWPPEIEEDEDDDPGSPCLEGKECERFFCCIEDCQTGMWREGRVRIHISRLDSYSRVFFPTAFLLFNIVYWIAYLYL
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Abundant in several brain regions; including the ectostriatum; nucleus rotundus and hyperstriatum ventrale
DOI ID
10.1016/0014-5793(93)80339-v
RefSeq
NP_990576.1